archive-es.com » ES » G » GAIKER.ES

Total: 803

Choose link from "Titles, links and description words view":

Or switch to "Titles and links view".
  • Oldartu 81
    News KTO Home News Publications Newsletter Press Releases Publications Annual report Newsletter Catalogs Monographs We interview Corporate Image Oldartu 81 Download December 2013 Si deseas recibir futuros newsletters suscríbete Go to newsletters list Back Clara Bilbao bilbaoc gaiker es 2016 GAIKER Technology Centre Parque Tecnológico Ed 202 48170 Zamudio Bizkaia SPAIN T 34 94 6002323 M 607 486 342 F 34 94 6002324 Site Map Links Accessibility Privacy Policy Legal

    Original URL path: http://www.gaiker.es/ing/newsletter/oldartu-81.aspx?id=993cae83-658a-483d-af8e-90a19ac87011&origen=publicaciones (2016-02-15)
    Open archived version from archive


  • Publications
    Releases Publications Annual report Newsletter Catalogs Monographs We interview Corporate Image Publications Newsletter Oldartu 79 Download July 2013 Oldartu 78 Download May 2013 Oldartu 77 Download February 2013 Oldartu 76 Download December 2012 Oldartu 75 Download September 2012 Oldartu 74 Download July 2012 Page 2 of 6 2016 GAIKER Technology Centre Parque Tecnológico Ed 202 48170 Zamudio Bizkaia SPAIN T 34 94 6002323 M 607 486 342 F 34 94

    Original URL path: http://www.gaiker.es/ing/publicaciones.aspx?tipo=1&pagina=1 (2016-02-15)
    Open archived version from archive

  • In Vitro Tests
    and sub cellular level Cell cultures are used to evaluate the toxicity and cell effectiveness of chemicals biological products drugs cosmetics or nanoparticles Our research team s expertise in this field involves the study of the alteration of the mechanisms of action involved in these processes through the study of cell molecular or proteomic markers Moreover the group focuses on the evaluation and prediction of the pharmacokinetic behaviour of drugs absorption metabolism drug interaction and protein binding through in vitro systems These studies are essential in drug development The activity undertaken by this team is framed within our GLP standard certification granted by the Ministry of Health and Social Policy Cytotoxicity Cytotoxicity tests on cell lines and primar y cultures NR incorporation MTT XTT LDH liberation ATP Alamar Blue etc Molecular mechanisms involved in cytotoxicity using flow cytometry techniques apoptosis necrosis superoxide radicals intracellular pH mitochondrial status etc Genetic toxicology Mutagenicity Reverse mutation test of salmonella typhimurium Ames test OECD TG 471 1983 In vitro mammalian cell gene mutation test OECD TG 476 Phototoxicity Incorporation of neutral red in 3T3 fibroblasts test OECD TG 432 Dermal corrosivity In vitro membrane barrier method test OECD TG 435 Invittox nº 116 Corrositex

    Original URL path: http://www.gaiker.es/ing/in_vitro.aspx?ventana=toxicidad (2016-02-15)
    Open archived version from archive

  • In Vitro Tests
    undertake studies involving the use of animal cell cultures Cells which can come from multiple organs and numerous species enable to reproduce at lab scale fast reliable and predictive systems to study the behaviour of drugs cosmetics and other products affecting human health at cellular and sub cellular level Cell cultures are used to evaluate the toxicity and cell effectiveness of chemicals biological products drugs cosmetics or nanoparticles Our research team s expertise in this field involves the study of the alteration of the mechanisms of action involved in these processes through the study of cell molecular or proteomic markers Moreover the group focuses on the evaluation and prediction of the pharmacokinetic behaviour of drugs absorption metabolism drug interaction and protein binding through in vitro systems These studies are essential in drug development The activity undertaken by this team is framed within our GLP standard certification granted by the Ministry of Health and Social Policy In vitro activity assessment Depending on the activity to be verified we design tests to focus on the parameter of interest culturing the cell type that best models the effects to be tested protein overexpression anti inflammatory effect hydration antioxidants etc using flow cytometry and

    Original URL path: http://www.gaiker.es/ing/in_vitro.aspx?ventana=eficacia (2016-02-15)
    Open archived version from archive

  • In Vitro Tests
    sub cellular level Cell cultures are used to evaluate the toxicity and cell effectiveness of chemicals biological products drugs cosmetics or nanoparticles Our research team s expertise in this field involves the study of the alteration of the mechanisms of action involved in these processes through the study of cell molecular or proteomic markers Moreover the group focuses on the evaluation and prediction of the pharmacokinetic behaviour of drugs absorption

    Original URL path: http://www.gaiker.es/ing/in_vitro.aspx?ventana=proteomicos (2016-02-15)
    Open archived version from archive

  • In Vitro Tests
    the study of the alteration of the mechanisms of action involved in these processes through the study of cell molecular or proteomic markers Moreover the group focuses on the evaluation and prediction of the pharmacokinetic behaviour of drugs absorption metabolism drug interaction and protein binding through in vitro systems These studies are essential in drug development The activity undertaken by this team is framed within our GLP standard certification granted by the Ministry of Health and Social Policy Absorption and metabolism Absorption and metabolism tests can be conducted in accordance to FDA regulations Guidance for industry Drug interaction studies study design data analysis and implications for dosing and labelling September 2006 Tests to study cell metabolism are conducted on animal or human hepatic microsomes or on primary cultures of suspended or plated hepatocytes Development improvement and validation of the appropriate chromatography technique to detect active ingredients and or its metabolites Definition of a product s metabolism pattern Study of microsome metabolic stability Calculation of metabolisation Comparative study of the metabolisation pattern of a product in the hepatic systems of different species Comparative interspecies microsome metabolism study Calculation of metabolisation Study of metabolism kinetics Definition of parameters Km Vmax Metabolite characterisation on the basis of its absorption and mass spectra Identification of CYP450 isozymes involved in product metabolism Monitoring Phase I and Phase II enzymes Interactions with other products Cytochrome inhibition Calculation of parameters Ki IC50 Cytochrome induction Calculation of induction percentage Permeability through Caco 2 cell culture Calculation of apparent permeability coefficient Papp Permeability screening Calculation of transport Identification of carriers through enzymatic and RT PCR techniques Instrumental analysis laboratory Waters ultra performance liquid chromatography device UPLC MS MS composed of an Aquity UPLC and a triple quadruple mass spectrometer Quattro micro APi with ESP and APCI interfaces High resolution

    Original URL path: http://www.gaiker.es/ing/in_vitro.aspx?ventana=metabolismo (2016-02-15)
    Open archived version from archive

  • Environmental Management - Projects
    context 2008 2010 ETORGAI Project Funded by the Basque Government Subject ecodesign Leader ZIV Development of a tool to identify and assess the sustainability of end of life processes Development of matter and energy flow models in several waste processing systems incineration gasification recycling cement recovery etc to simulate the treatment of each type of waste depending on its composition with the ultimate goal of calculating life cycle environmental indicators 2008 Private funding from client Subject LCA Critical review of the study Comparative life cycle assessment of two options for waste tyre treatment recycling in asphalt and incineration in cement kilns Critical review of the study performed by the Danish Topic Centre on Waste and IFEU according to the requirements of the ISO 14044 standard on Life Cycle Analysis for comparative studies which will be made public 2008 2009 Subject Life Cycle Assessment A study of the application of the extended producer responsibility EPR principle from the WEEE Waste Electrical and Electronic Equipment Directive in the household appliances sector implications of environmental legislation on aspects of ecodesign Advantages and environmental and economic problems associated with the extended producer responsibility EPR concept posed by various industrial associations 2007 2008 Private funding from client Subject ecodesign environmental legislation Review of Directive 2002 96 on Waste Electrical and Electronic Equipment WEEE Environmental Economic and Social Impacts Assessment Options for Improvement Project awarded by the EC DG Environment by public tender to UNU EHS AEA Technology TU Delft GAIKER IK4 and REC Critical analysis of the options for improving the WEEE Directive during its revision in 2008 2006 2007 7FP European Project Subject ecodesign environmental legislation Leader UNU EHS Development of a geographic information system for the sustainable management of industrial and technology parks G park Development of a geographic information system enabling the

    Original URL path: http://www.gaiker.es/ing/gestion_proyectos2.aspx (2016-02-15)
    Open archived version from archive

  • Thermosets - Projects
    which GAIKER IK4 leads the topic on highly carbonisable composites which are environmentally friendly given their natural origin 2011 2015 PEuropean Project 7FP Subject fireproofing Leader Newcastle University Research and development of new energy generation technologies based on thin film photovoltaic cells ATON Development and adaptation of substrates glass polymers steel and ceramic for new photovoltaic absorbers Development of new formulations to adjust the properties to maximise the efficiency of the device and to optimise the mechanical properties of the set durability while facilitating their integration architecture 2009 2012 CENIT Project Funded by the CDTI Spanish Centre for Industrial Technological Development Spanish Ministry of Science and Innovation Subject high performance prepreg polymers Leader Grupo Unisolar Development of applications based in plastic materials and composites obtained from renewable non petroleum based biological sources BIOBASED MATERIALS The project involves technology development and modification of bioplastics and biocomposites of thermoplastic and thermoset nature for industrial prototypes validated technically economically and environmentally with respect to the reference products 2009 2011 ETORGAI Project Funded by the Basque Government Subject natural composites Leader Maier S Coop Recycling thermoset composites of the SST EURECOMP Development of an adequate solvolysis process for recycling and reusing thermoset composites in

    Original URL path: http://www.gaiker.es/ing/materiales_termoestables_proyectos2.aspx (2016-02-15)
    Open archived version from archive



  •