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  • Research Groups - iib.uam.es
    Biology Department Department of Endocrine and Nervous System Pathophysiology Department of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Laboratory of Carlos Gancedo Rodríguez Introduction Sorry we cannot display the information requested at this time Gancedo Rodríguez Carlos Dr Ad Honorem Introduction Staff Research topics Publications Additional Information Navigation Presentation Welcome Location History Biography of Alberto Sols Organization Organization

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=17&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=77&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=intro (2015-08-08)
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  • Research Groups - iib.uam.es
    as one of the most important public health problems facing the world today Prevalence is growing exponentially worldwide both in developed and developing countries An increased intake of energy dense foods especially when combined with reduced physical activity surely contributes to this high prevalence Obesity is defined medically as a state of increased adipose tissue of such magnitude to produce adverse health consequences Obese subjects have an increased risk of suffering insulin resistance type 2 diabetes and cardiovascular disease among others Previously considered an inert depot fat is now regarded as a key highly active and versatile organ with many important physiological and pathological roles Most of the adipose tissue functions are carried out via molecules secreted by fat cells capable of acting locally and in many non adipose tissues such as muscle liver and stomach tissues as well as nervous immune and vascular systems In humans the adipose tissue is mainly shown in two compartments the subcutaneous and the visceral fat depots Numerous methods have been developed to study the adipose tissue among them Proteomics Proteomics is the large scale study of proteins in disease related processes at the whole cell or tissue level and even in subcellular structures and in biological fluids We have used this approach in our laboratory and several comparative proteomic studies have been performed based on 2D DIGE and Mass Spectrometry currently considered pioneers in the field of obesity In a first study the subcutaneous and omental adipose tissue proteomes were compared highlighting the elevated metabolic activity and the higher inflammatory profile of the omental versus the subcutaneous fat in a second study the omental adipose tissue from obese and non obese subjects was compared underlining a clear distinctive proteomic pattern between the two group of individuals which underscore a reduced metabolic activity together

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=67&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=516&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=intro (2015-08-08)
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  • Research Groups - iib.uam.es
    Cancer Biology Department Department of Endocrine and Nervous System Pathophysiology Department of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Laboratory of Rafael Garesse Alarcón Introduction Sorry we cannot display the information requested at this time Garesse Alarcón Rafael Catedrático Introduction Staff Research topics Publications Additional Information Navigation Presentation Welcome Location History Biography of Alberto Sols Organization Organization chart

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=49&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=89&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=intro (2015-08-08)
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  • Research Groups - iib.uam.es
    Biology Department Department of Endocrine and Nervous System Pathophysiology Department of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Laboratory of Ana María Pérez Castillo Introduction Sorry we cannot display the information requested at this time Pérez Castillo Ana María Profesor Investigación Introduction Staff Research topics Publications Additional Information Navigation Presentation Welcome Location History Biography of Alberto Sols Organization

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=27&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=201&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=intro (2015-08-08)
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  • Research Groups - iib.uam.es
    Research Research Groups Research Groups Research Departments Cancer Biology Department Department of Endocrine and Nervous System Pathophysiology Department of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Laboratory of Borja Belandia Gómez Introduction Nuclear hormone receptors NRs are ligand dependent transcription factors that control multiple processes during the embryonic development and they play a central role in the control of cell proliferation cell differentiation and in the homeostasis in the adult Alterations in the normal function of NRs due to mutations in the genes encoding NRs or any of the proteins required for their action cause many diseases in humans including several types of cancer Our laboratory is interested in the study of the molecular mechanisms by which NRs regulate gene expression focussing on the characterization of novel NR transcriptional co regulators and the study of their possible role in the origin and development of tumours in endocrine regulated tissues such as the mammary gland and the prostate Belandia Gómez Borja Científico Titular Introduction Staff Research topics Publications Additional Information Navigation Presentation Welcome Location History Biography of Alberto Sols Organization Organization chart Management Administration Institute Board Faculty Board Committees

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=88&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=18&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=intro (2015-08-08)
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  • Research Groups - iib.uam.es
    Cell Cultures Non Invasive Neurofunctional Evaluation ENNI Histology Scientific Photography and Drawing Facility Sterilization and Culture Media Preparation Radiation Protection Genomics MRISS IT Services SIME Microscopy Directory Activities Calendar Scientific Events News RSS feed aggregators Intranet Internal Tools Internal Information iib uam es Research Research Groups Research Groups Research Departments Cancer Biology Department Department of Endocrine and Nervous System Pathophysiology Department of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Ion Channels Lab II Introduction We focus in the analysis of the pharmacological and physiological modulation of human cardiac ion channels and in the composition and regulation of their signal complexes In order to perform our investigations we use patch clamp and molecular biology techniques González Gallego Teresa Investigador Contratado Introduction Staff Research topics Publications Additional Information Navigation Presentation Welcome Location History Biography of Alberto Sols Organization Organization chart Management Administration Institute Board Faculty Board Committees Commissions Research Research Groups Research Departments Scientific Reports Publications Services Administration and Accounting Warehouse Digital Library Quality Control Labware Washing Facility Technical Support Biological Safety Comparative Medicine Cell Cultures Non Invasive Neurofunctional Evaluation ENNI Histology Scientific Photography and Drawing Facility Sterilization and Culture

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=1014&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=1316&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=intro (2015-08-08)
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  • Research Groups - iib.uam.es
    Histology Scientific Photography and Drawing Facility Sterilization and Culture Media Preparation Radiation Protection Genomics MRISS IT Services SIME Microscopy Directory Activities Calendar Scientific Events News RSS feed aggregators Intranet Internal Tools Internal Information iib uam es Research Research Groups Research Groups Research Departments Cancer Biology Department Department of Endocrine and Nervous System Pathophysiology Department of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Thyroid hormones and brain Introduction The goal of our group is to define the molecular mecanisms of thyroid hormone action in the brain both during development and in adult animals We use rats and mice as animal models Especial attention is paid to the role of nuclear receptors for thyroid hormone as well as the identification of the target genes Bernal Carrasco Juan Profesor Investigación Introduction Staff Research topics Publications Additional Information Navigation Presentation Welcome Location History Biography of Alberto Sols Organization Organization chart Management Administration Institute Board Faculty Board Committees Commissions Research Research Groups Research Departments Scientific Reports Publications Services Administration and Accounting Warehouse Digital Library Quality Control Labware Washing Facility Technical Support Biological Safety Comparative Medicine Cell Cultures Non Invasive Neurofunctional Evaluation ENNI Histology

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=32&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=23&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=intro (2015-08-08)
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  • Research Groups - iib.uam.es
    point of view macrophage activation can be classified as pro inflammatory M1 polarization anti inflammatory M2 or pro resolution deactivation M0 these profiles coexisting in the course of the immune response A line of interest has been the characterization of signaling pathways that determine the polarization and its effect on the release of mediators of inflammation In addition to this these mediators affect the function and gene expression in differentiated cells such as hepatocytes cardiomyocytes and myofibroblasts We recently analyzed the metabolic aspects associated with macrophage activation trying to answer the question about what changes in the regulation of energy metabolism and precursors NADPH riboses etc accompany the different types of polarization and to what extent these changes are necessary for the activation phenotype To get an idea of the magnitude of changes involved for example after M1 activation through TL4 challenge there is an alteration in the expression of over a thousand of genes The interest of these studies is to envisage the possibility to regulate macrophage function by altering their metabolic activity as a complementary strategy to regulate their participation in the inflammatory response We could show that regardless of the stimulus used and the availability of energy substrates the macrophage is in more than 90 glycolytic with limited use of other fuels for energy purposes however the pathways to generate metabolites from the TCA and glutaminolysis are fully functional and these molecules are used for other purposes The other area of interest in the group is the study of the role of macrophages that infiltrate the tissues under pathophysiological situations Following an ischemic process or in the course of infectious myocarditis the heart elicits an inflammatory response that promotes the infiltration and activation of resident and circulating inflammatory cells representing up to 4 5 of the heart

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=107&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=1292&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=intro (2015-08-08)
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