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  • Research Groups - iib.uam.es
    role of thyroid hormones action in the central nervous system Introduction Our research focuses on understanding the role of thyroid hormones T4 or thyroxine and T3 or 3 5 3 triiodothyronine action in the central nervous system CNS both during development and in adult stages We are especially interested in the identification of structural and or functional alterations in the CNS due to defects in thyroid hormones availability or signaling situations To achieve this goal we analyze the phenotype of experimental animals deficient in proteins involved in the metabolism and plasma membrane transport of thyroid hormones using different experimental approaches We perform in vivo studies to characterize the structural and functional consequences of situations with an abnormal availability of thyroid hormones in the CNS We also analyze the histopathology of human autopsy brain tissues from Allan Herndon Dudley syndrome patients This syndrome is due to mutations in the monocarboxylate transporter 8 MCT8 SLC16A2 an important thyroid hormones transporter in the brain Our studies will shed light on the pathophysiology and on the CNS disease mechanisms associated to defects in thyroid hormones signaling and will even contribute to the development of new therapeutic strategies These studies will also help to better

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=94&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=100&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=intro (2015-08-08)
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  • Research Groups - iib.uam.es
    strategies for the prevention or treatment of neurodegenerative disorders Our research group is focussed on the study of PKD Protein Kinase D and its substrate Kidins220 Kinase D interacting substrate of 220 kDa in order to define their role in neuronal physiopathology Particularly we are interested in studying the function of these two molecules in neuronal development and maturation survival and death Kidins220 is an evolutionary conserved transmembrane protein with unique features which presents one single gene from C elegans to humans We cloned Kidins220 as the first physiological substrate identified for PKD1 Some of the functions of this protein are now starting to be deciphered being its role as an efector of neurotrophin signalling the better known We have discovered that Kidins220 is crucial for neuronal survival Under excitotoxic conditions such as the ones produced in brain ischemia it undergoes a strong downregulation mediated by calpain proteolysis Excitotoxicity is a type of neuronal death induced by toxic concentrations of glutamate through overactivation of N methyl d aspartate receptors NMDARs that takes place in acute or chronic cerebral damage and participates in neuronal loss associated with Alzheimer s disease and other neurodegenerative diseases In addition we have shown that Kidins220 controls axonal establishment and elongation as well as dendritic development and neuronal maturation by binding and modulating microtubule regulatory proteins such as the microtubule associated proteins MAP1B and MAP2 Microtubule disorganization axonopathies and the alteration of neuronal cytoarchitecture are early events in Alzheimer s disease pathogenesis MAP1B and MAP2 are sequestered by hyperphosphorylated tau in neurofibrillary tangles one of the major hallmarks of this disease All together these data led us to hypothesize that Kidins220 could be altered in Alzheimer s disease During the last year we have published that Kidins220 is increased in human brain necropsies from Alzheimer s

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=69&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=463&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=intro (2015-08-08)
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  • Research Groups - iib.uam.es
    by inward budding of the limiting membrane of late endosomes into their lumen The exosomes accumulate as intraluminal vesicles into secretory vesicles multivesicular bodies MVBs The stimulation of cells from diverse lineages induces the fusion of the limiting membrane of the MVBs with the plasma membrane and the secretion of exosomes Fig 1 Several evidences support the hypothesis that exosomes represent a novel modality of intercellular communication particullarly in the immune system In the immune system T lymphocyte activation with antigen through the T cell receptor TCR induces the acquisition of essential effector functions and controls the activation proliferation and apoptosis of T lymphocytes In some of these biological responses which include the cytotoxic activity exerted by cytotoxic T lymphocytes CTLs T lymphocyte activation and activation induced cell death AICD processes the exosomes appear to play an important role The MVBs from cytotoxic T lymphocytes CTLs are called lytic granules Fig 1 Upon challenge with antigen CTLs develop different mechanisms to induce the apoptosis of target cells Included among these strategies the inducible expression of Fas ligand FasL in lytic granules and its polarized secretion at the immune synapse are thought to be important mediators of CTL mediated killing In addition FasL contributes to the homeostatic control of the T lymphoid compartment that occurs through activation induced cell death AICD Regarding FasL function it has been shown that the secretion of bioactive apoptosis inducer FasL into exosomes constitutes an important mechanism controlling FasL activity Therefore our aims are 1 To gain insights into the mechanisms by which T lymphocytes control the polarised traffic of MVBs lytic granules and regulate the secretion of exosomes 2 To establish the role of pro apoptotic exosomes in the cytotoxicity mediated by CTLs and homeostatic AICD With all these knowledge in hand it will be

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=81&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=987&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=intro (2015-08-08)
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  • Research Groups - iib.uam.es
    RSS feed aggregators Intranet Internal Tools Internal Information iib uam es Research Research Groups Research Groups Research Departments Cancer Biology Department Department of Endocrine and Nervous System Pathophysiology Department of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Molecular characterization of tumor formation and vascular pathologies development Introduction We are searching for genes participating in neoplastic transformation that may become therapeutic targets To this end we compare the transcriptomes of transformed and immortalized cells We assess the contribution of these genes to the progression of immortalized cells to a transformed state using both cell and animal models We also search for genes mediating pathological vascular wall remodeling a key process in the development of hypertension atherosclerosis aneurysm and restenosis We determine the contribution of these genes to vessel remodeling using mouse models for these pathologies primary cells cultures and numerous approaches based in molecular and cell biology Campanero García Miguel Científico Titular Introduction Staff Research topics Publications Additional Information Navigation Presentation Welcome Location History Biography of Alberto Sols Organization Organization chart Management Administration Institute Board Faculty Board Committees Commissions Research Research Groups Research Departments Scientific Reports Publications Services Administration

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=71&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=681&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=intro (2015-08-08)
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  • Research Groups - iib.uam.es
    angiogenesis Introduction Cancer is a complex disease in which the microenvironment plays a relevant role Endothelial cells are an essential component of the tumor microenvironment and their activation to form new blood vessels is a fundamental process to maintain the growth of the primary tumor for the dissemination of tumor cells to distant organs and for the growth of metastases The formation of new capillaries named angiogenesis is controlled by the balance of positive regulatory factors inducers of angiogenesis and negative regulatory factors inhibitors of angiogenesis produced by the cells of every tissue of an organism Our group is focused on the study of the mechanism of action of two inhibitors of angiogenesis thrombospondin 1 TSP 1 and pigment epithelium derived factor PEDF We use human cellular models and murine tumor models for the study of the mechanism of action of these factors and their antiangiogenic and antimetastatic potential We perform angiogenesis assays based on dermal human microvascular endothelial cells and in vivo angiogenesis assays in mice We complement these approaches with studies in human biopsies of tumors especially in melanoma Our research has allowed us to unveiled fundamental aspects of the mechanism of action of TSP 1 and PEDF

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=72&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=111&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=intro (2015-08-08)
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  • Research Groups - iib.uam.es
    Endocrine and Nervous System Pathophysiology Department of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Santisteban Sanz Pilar Introduction Our studies in the past years have been focused on understanding the molecular mechanisms that control cell differentiation and proliferation during development and transformation Every day it is more accepted that both processes share similar mechanism of regulation at the transcription and signal transduction levels A paradigm for studying these processes are the organs derived from the endoderm as development and cancer can be well studied using different animal models and cell systems We have focused our investigation on the thyroid gland an organ derived from the endoderm that is responsible for thyroid hormone biosynthesis This organ model is well suited for studying embryonic development and mechanisms involved in differentiation and proliferation We believe that understanding these processes is by no means solely academic since identification of the inductive molecules involved in thyroid development and thyroid proliferation and differentiation will likely provide clues to novel pathogenetic mechanisms of thyroid disorders in human Santisteban Sanz Pilar Profesor Investigación Introduction Staff Research topics Publications Additional Information Navigation Presentation Welcome Location History Biography

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=31&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=237&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=intro (2015-08-08)
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  • Research Groups - iib.uam.es
    Stay at Harvard Medical School 1993 1994 USA Group Leader in the Biochemistry Department at the School of Medicine UAM since 1986 Full Professor of Biochemistry since 2007 Professor Cervera has served as coordinator of the Ph D program at the Biochemistry Department since 2000 to 2007 as Vice director of the Instituto Investigaciones Biomédicas Biomedical Research Centre a joint UAM CSIC centre secretary of the Department of Biochemistry at the UAM and as Academic Secretary of the School of Medicine at the UAM Research Interest In the Cervera lab a group of research associates postdoctoral fellows Ph D candidates master s students and undergraduates collaborate to study the basic regulatory mechanisms that modulate levels of transcription in the development of muscle diversity The lab produces transgenic strains of Drosophila to study how muscle gene regulatory regions affect expression levels in muscle subtypes and during muscle development In parallel we are also studying the relevance of the phenotypic and functional changes in coordinated mitochondrial production during muscle development Thus we will examine the magnitude of the adaptive increase or decrease in skeletal muscle mitochondrial content in response to development or re modelling in different pathologies The lab adopts integrated strategies for these studies transgenic studies comparative genomics bioinformatics quantitative RT PCR functional studies of the muscle in vivo transfection of muscle fibres in situ hybridisation and immuno staining to study patterns of expression in muscle In the lab we will take advantage of different cell model systems as human or Drosophila myoblastoid cells or animal models such as Drosophila or mouse The lab has operated for nearly 25 years with funding from the European Union National and Community Plans Professor Cervera has collaborated with academics from Spain universities from the University of California in San Diego From the EMBL in

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=62&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=39&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=intro (2015-08-08)
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  • Research Groups - iib.uam.es
    Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Magnetic resonance in the study of the central nervous system Introduction Cancer is one of the main caused of death in EU and other developed countries Current techniques can only diagnose and treat the late symptoms of cancer what it is getting this disease in a chronic process Nowadays there are more then 30 angiogenic inhibitors in clinical trials nevertheless there are not appropriate procedures to visualize and monitor the effectiveness of these therapies Magnetic Resonance Imaging MRI Spectroscopy MRS and Spectroscopic Imaging MRSI technologies provide a great potential to solve this situation in a near future These methodologies make possible the in vivo study among other parameters of vascularization oxygenation level pH and tumoral metabolism in a non invasive way allowing direct monitoring of different antitumoral therapies In our research group the main objective is focused in the development of new MR methodologies that afford the possibility of in vivo characterization of the tumoral microenvironment and visualization of neovascularization and tumoral metabolism That will drive us to a better understanding of the physiological and biochemical bases of connections between these parameters López Larrubia Pilar Científico Titular

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=113&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=820&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=intro (2015-08-08)
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