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  • Research Groups - iib.uam.es
    of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Laboratory of Jesús Cruces Pinto Introduction Our group focuses its work on the study of dystroglycanopathies a type of muscle diseases with different neuronal impairment degrees due to incorrect O glycosylation of alpha dystroglycan a protein crucial for basement membranes of many cells including muscle and neuronal cells Besides molecular diagnostic studies in Spanish and foreign patients carrying these pathologies we are studying the function of several genes responsible for these diseases as FKTN and FKRP whose exact function is still unknown in the alpha dystroglycan O glycosylation process Also we are generating animal models conditional KOs for POMT1 the main and first enzyme involved in the synthesis of the alpha dystroglycan O mannosylglycan chain to know its function in brain muscle and also in the ocular system see project s page for the study of ocular involvement And finally we are also studying the involvement of the glycosylation of dystroglycan in the development progression and invasion of several types of cancer since the interaction between the tumour cell and the extracellular matrix is a key point in the tumoral process Cruces Pinto Jesús Catedrático Introduction

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=47&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=43&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=intro (2015-08-08)
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  • Research Groups - iib.uam.es
    Endocrine and Nervous System Pathophysiology Department of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Dual role of COX 2 in liver pathology Introduction Cyclooxygenase COX is a key regulatory step in the biosynthesis of prostanoids Prostaglandins are implicated in homeostatic processes like platelet aggregation maintaining of gastric mucose reproduction etc in addition these compounds play an important role in the onset of inflammation mitogenic responses and cancer Two COX isoenzymes have been identified COX 1 is ubiquitous and constitutively expressed in a wide variety of tissues and is responsible for the low and continuous prostaglandin synthesis required in tissue homeostasis COX 2 is undetectable in most tissues however a variety of extracellular and intracellular stimuli such inflammation and other cellular stresses can rapidly induce COX 2 in a variety of cell types COX 2 is also related with cellular growth and carcinogenesis Our group study the relationship between COX 2 expression and liver pathology by using different experimental models and human biopsies and the molecular mechanisms implicated in these processes Martín Sanz Paloma Investigador Científico Introduction Staff Research topics Publications Additional Information Navigation Presentation Welcome Location History Biography

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=110&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=1291&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=intro (2015-08-08)
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  • Research Groups - iib.uam.es
    Cancer Biology Department Department of Endocrine and Nervous System Pathophysiology Department of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Ion channels laboratory I Introduction Our research team studies the physiological and pharmacological modulation of ion channels present in the plasma membrane of human cardiac myocytes In order to assess this issue we use the whole cell configuration of the patch clamp technique Ionic channels are membrane proteins able to generate and maintain the action potential duration and also to maintain the resting membrane potential Therefore these molecules are responsible among other functions of muscle contraction cardiac rhythm and synaptic transmission We focus our resarch interest in the potassium channels present into the human myocardium In the heart IKur current represents the more important potassium outward currents during the atrial repolarization The IKur is generated after the activation of Kv1 5 channels Because these channels are responsible of the atrial cardic repolarization they represent pharmacological targets of antiarrhythmic drugs useful in the treatment of cardiac arrhythmias Valenzuela Miranda Carmen Investigador Científico Introduction Staff Research topics Publications Additional Information Navigation Presentation Welcome Location History Biography of Alberto Sols Organization Organization

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=108&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=869&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=intro (2015-08-08)
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  • Research Groups - iib.uam.es
    Department of Endocrine and Nervous System Pathophysiology Department of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Laboratory of Mario Vallejo Fdez de la Reguera Introduction Sorry we cannot display the information requested at this time Vallejo Fdez de la Reguera Mario Profesor Investigación Introduction Staff Research topics Publications Additional Information Navigation Presentation Welcome Location History Biography of Alberto

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=66&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=475&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=intro (2015-08-08)
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  • Research Groups - iib.uam.es
    Department Department of Endocrine and Nervous System Pathophysiology Department of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Laboratory of Oscar Hernan Martínez Costa Pérez Introduction Sorry we cannot display the information requested at this time Martínez Costa Pérez Oscar Hernan Contratado Doctor Introduction Staff Research topics Publications Additional Information Navigation Presentation Welcome Location History Biography of Alberto Sols

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=100&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=450&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=intro (2015-08-08)
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  • Research Groups - iib.uam.es
    Departments Cancer Biology Department Department of Endocrine and Nervous System Pathophysiology Department of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Bioinformatics Introduction Our main research area is bioinformatics especially computational statistics applied to the analysis of high throughput data mainly in cancer Our work ranges from the application of standard techniques to the development of new statistical approaches with special emphasis in their implementation using high performance computing Some of the problems we have worked on include patient classification and gene differential expression using microarray expression data survival analysis with omics data functional annotation of results from analysis of omics experiments and in the last years mainly segmentation of array CGH data to detect copy number changes in genomic DNA and to identify recurrent regions of alteration in groups of patients Our current work involves the use of phylogenetic methods and probabilistic graphical model to address problems of detecting recurrent regions of alteration in copy number and to discover tumor development paths and trajectories Díaz Uriarte Ramón Profesor Titular Introduction Staff Research topics Publications Additional Information Navigation Presentation Welcome Location History Biography of Alberto Sols Organization Organization chart

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=1000&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=3009&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=intro (2015-08-08)
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  • Research Groups - iib.uam.es
    Department of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Neurobiology of Hearing Introduction Molecular and Cellular Bases of Hearing and Deafness role of insulin like growth factors Publications Varela Nieto I http www ncbi nlm nih gov pubmed term varela nieto 20i www targear eu Varela Nieto Isabel Profesor Investigación Introduction Staff Research topics Publications Additional Information Navigation

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=23&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=258&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=intro (2015-08-08)
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  • Research Groups - iib.uam.es
    in pdf format Publications Laboratory of Margarita Díaz Guerra González Introduction Neurotrasmitters and neurotrophic factors play fundamental roles in developing and adult mammalian nervous system and a tightly regulated interplay between glutamate and BDNF signaling has been previously described Glutamate mainly throughout activation of the NMDA type of receptors NMDARs is central to synaptic plasticity learning and memory as well as survival death pathways The activation by BDNF of its high affinity TrkB receptor is likewise important The NMDARs are dichotomous molecules also involved in diverse pathologies including brain ischemia and neurodegenerative disorders in which delayed neuronal death is mainly due to excitotoxicity induced by overstimulation of these receptors Similarly dysfunction of BDNF TrkB pathways has been reported in some neurodegenerative diseases but to date evidence of similar modifications in stroke is lacking Interestingly decreased BDNF TrkB signaling has been also proposed as a pathological mechanism of depression a highly prevalent psychiatric condition among stroke survivors In our laboratory we are trying to characterize if NMDAR and BDNF TrkB pathways are also interrelated under pathological conditions such as those found in cerebrovascular diseases By analyzing the coordinated regulation of these proteins we will 1 get a better knowledge of the pathological mechanisms underlying stroke post stroke depression and perhaps neurodegenerative diseases 2 develop mechanism based surrogate markers of brain damage to improve the diagnosis of ischemic stroke 3 identify new molecular targets for neuroprotection and 4 develop novel therapeutic strategies in stroke and neurodegenerative diseases Our work is planned as a comprehensive study where we are using several experimental paradigms animal models of cerebral ischemia where excitotoxicity takes place in vivo and cellular models based on NMDAR agonist treatment of primary cultures of cortical neurons More important findings are also being challenged in human samples from patients suffering cerebrovascular disease

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=84&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=272&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=intro (2015-08-08)
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