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  • Cancer Biology Department - iib.uam.es
    Publications Tumor angiogenesis Introduction Cancer is a complex disease in which the microenvironment plays a relevant role Endothelial cells are an essential component of the tumor microenvironment and their activation to form new blood vessels is a fundamental process to maintain the growth of the primary tumor for the dissemination of tumor cells to distant organs and for the growth of metastases The formation of new capillaries named angiogenesis is controlled by the balance of positive regulatory factors inducers of angiogenesis and negative regulatory factors inhibitors of angiogenesis produced by the cells of every tissue of an organism Our group is focused on the study of the mechanism of action of two inhibitors of angiogenesis thrombospondin 1 TSP 1 and pigment epithelium derived factor PEDF We use human cellular models and murine tumor models for the study of the mechanism of action of these factors and their antiangiogenic and antimetastatic potential We perform angiogenesis assays based on dermal human microvascular endothelial cells and in vivo angiogenesis assays in mice We complement these approaches with studies in human biopsies of tumors especially in melanoma Our research has allowed us to unveiled fundamental aspects of the mechanism of action of TSP 1

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/unidades/dep_cancer?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_aV39&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_aV39_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_aV39_id=72&_APGIportlet_WAR_APIIBportlet_INSTANCE_aV39_idJefe=111&_APGIportlet_WAR_APIIBportlet_INSTANCE_aV39_menu=intro (2015-08-08)
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  • Cancer Biology Department - iib.uam.es
    feed aggregators Intranet Internal Tools Internal Information iib uam es Research Research Departments Cancer Biology Department Research Groups Research Departments Cancer Biology Department Department of Endocrine and Nervous System Pathophysiology Department of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Molecular characterization of tumor formation and vascular pathologies development Introduction We are searching for genes participating in neoplastic transformation that may become therapeutic targets To this end we compare the transcriptomes of transformed and immortalized cells We assess the contribution of these genes to the progression of immortalized cells to a transformed state using both cell and animal models We also search for genes mediating pathological vascular wall remodeling a key process in the development of hypertension atherosclerosis aneurysm and restenosis We determine the contribution of these genes to vessel remodeling using mouse models for these pathologies primary cells cultures and numerous approaches based in molecular and cell biology Campanero García Miguel Científico Titular Introduction Staff Research topics Publications Additional Information Navigation Presentation Welcome Location History Biography of Alberto Sols Organization Organization chart Management Administration Institute Board Faculty Board Committees Commissions Research Research Groups Research Departments Scientific Reports Publications

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/unidades/dep_cancer?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_aV39&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_aV39_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_aV39_id=71&_APGIportlet_WAR_APIIBportlet_INSTANCE_aV39_idJefe=681&_APGIportlet_WAR_APIIBportlet_INSTANCE_aV39_menu=intro (2015-08-08)
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  • Cancer Biology Department - iib.uam.es
    Research Departments Cancer Biology Department Department of Endocrine and Nervous System Pathophysiology Department of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Laboratory of Amparo Cano García Introduction Sorry we cannot display the information requested at this time Cano García Amparo Catedrático Introduction Staff Research topics Publications Additional Information Navigation Presentation Welcome Location History Biography of Alberto Sols Organization

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/unidades/dep_cancer?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_aV39&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_aV39_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_aV39_id=28&_APGIportlet_WAR_APIIBportlet_INSTANCE_aV39_idJefe=32&_APGIportlet_WAR_APIIBportlet_INSTANCE_aV39_menu=intro (2015-08-08)
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  • Cancer Biology Department - iib.uam.es
    Cancer Biology Department Research Groups Research Departments Cancer Biology Department Department of Endocrine and Nervous System Pathophysiology Department of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Laboratory of Antonio Villalobo Polo Introduction Our research is focused on the understanding of new regulatory mechanisms implicated in the control of cell proliferation cell migration and intercellular communication and their alterations in tumor cells The current ongoing projects in the lab are as follow i The control of the functionality of the adaptor proteins Grb7 Grb10 and Grb14 mediated by calmodulin ii The control exerted by calmodulin on the ligand dependent activation of the epidermal growth factor receptor EGFR and other ErbB receptors in living cells iii The regulation exerted by nitric oxide on cell proliferation particularly the study of its action on the EGFR and its downstream signaling pathways and on the control of the cell cycle and iv Regulation of tyrosine kinase receptors and components of their signaling pathways by O GlcNAcylation Villalobo Polo Antonio Profesor Investigación Introduction Staff Research topics Publications Additional Information Navigation Presentation Welcome Location History Biography of Alberto Sols Organization Organization chart Management Administration Institute

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/unidades/dep_cancer?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_aV39&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_aV39_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_aV39_id=22&_APGIportlet_WAR_APIIBportlet_INSTANCE_aV39_idJefe=265&_APGIportlet_WAR_APIIBportlet_INSTANCE_aV39_menu=intro (2015-08-08)
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  • Cancer Biology Department - iib.uam.es
    Groups Research Departments Cancer Biology Department Department of Endocrine and Nervous System Pathophysiology Department of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Bioinformatics Introduction Our main research area is bioinformatics especially computational statistics applied to the analysis of high throughput data mainly in cancer Our work ranges from the application of standard techniques to the development of new statistical approaches with special emphasis in their implementation using high performance computing Some of the problems we have worked on include patient classification and gene differential expression using microarray expression data survival analysis with omics data functional annotation of results from analysis of omics experiments and in the last years mainly segmentation of array CGH data to detect copy number changes in genomic DNA and to identify recurrent regions of alteration in groups of patients Our current work involves the use of phylogenetic methods and probabilistic graphical model to address problems of detecting recurrent regions of alteration in copy number and to discover tumor development paths and trajectories Díaz Uriarte Ramón Profesor Titular Introduction Staff Research topics Publications Additional Information Navigation Presentation Welcome Location History Biography of Alberto Sols Organization

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/unidades/dep_cancer?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_aV39&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_aV39_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_aV39_id=1000&_APGIportlet_WAR_APIIBportlet_INSTANCE_aV39_idJefe=3009&_APGIportlet_WAR_APIIBportlet_INSTANCE_aV39_menu=intro (2015-08-08)
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  • Cancer Biology Department - iib.uam.es
    of Endocrine and Nervous System Pathophysiology Department of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Laboratory of Alberto Muñoz Terol Introduction 1alpha 25 dihydroxyvitamin D3 the most active vitamin D derivative is synthesized in the kidney several epithelia and diverse cell types of the immune system 1alpha 25 dihydroxyvitamin D3 is a pleiotropic hormone that in addition to regulate calcium and phosphate metabolism and bone biology inhibits cell proliferation and invasion sensitizes to apoptosis and reduces angiogenesis and metastasis Our group investigates 1alpha 25 dihydroxyvitamin D3 action in colon cancer the effects on the phenotype of colon carcinoma cells by identifiying and studying its target genes the antagonism of the Wnt beta catenin canonical and non canonical signalling pathways and the interaction with factors such SNAIL1 2 and ZEB1 2 that induce epithelial to mesenchymal transition Recently we have initiated the study of the action of 1alpha 25 dihydroxyvitamin D3 on human colon normal and cancer stem cells and on stromal fibroblasts isolated from healthy and tumoral biopsies from colorectal cancer patients Muñoz Terol Alberto Profesor Investigación Introduction Staff Research topics Publications Additional Information Navigation Presentation Welcome Location

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/unidades/dep_cancer?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_aV39&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_aV39_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_aV39_id=33&_APGIportlet_WAR_APIIBportlet_INSTANCE_aV39_idJefe=173&_APGIportlet_WAR_APIIBportlet_INSTANCE_aV39_menu=intro (2015-08-08)
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  • Department of Endocrine and Nervous System Pathophysiology - iib.uam.es
    System Pathophysiology Research Groups Research Departments Cancer Biology Department Department of Endocrine and Nervous System Pathophysiology Department of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Laboratory of Ana Aranda Iriarte Introduction Sorry we cannot display the information requested at this time Aranda Iriarte Ana Profesor Investigación Introduction Staff Research topics Publications Additional Information Navigation Presentation Welcome Location History

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/unidades/dep_fisio?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_E1za&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_E1za_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_E1za_id=30&_APGIportlet_WAR_APIIBportlet_INSTANCE_E1za_idJefe=10&_APGIportlet_WAR_APIIBportlet_INSTANCE_E1za_menu=intro (2015-08-08)
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  • Department of Endocrine and Nervous System Pathophysiology - iib.uam.es
    the possibilities to develop novel therapeutic strategies for the prevention or treatment of neurodegenerative disorders Our research group is focussed on the study of PKD Protein Kinase D and its substrate Kidins220 Kinase D interacting substrate of 220 kDa in order to define their role in neuronal physiopathology Particularly we are interested in studying the function of these two molecules in neuronal development and maturation survival and death Kidins220 is an evolutionary conserved transmembrane protein with unique features which presents one single gene from C elegans to humans We cloned Kidins220 as the first physiological substrate identified for PKD1 Some of the functions of this protein are now starting to be deciphered being its role as an efector of neurotrophin signalling the better known We have discovered that Kidins220 is crucial for neuronal survival Under excitotoxic conditions such as the ones produced in brain ischemia it undergoes a strong downregulation mediated by calpain proteolysis Excitotoxicity is a type of neuronal death induced by toxic concentrations of glutamate through overactivation of N methyl d aspartate receptors NMDARs that takes place in acute or chronic cerebral damage and participates in neuronal loss associated with Alzheimer s disease and other neurodegenerative diseases In addition we have shown that Kidins220 controls axonal establishment and elongation as well as dendritic development and neuronal maturation by binding and modulating microtubule regulatory proteins such as the microtubule associated proteins MAP1B and MAP2 Microtubule disorganization axonopathies and the alteration of neuronal cytoarchitecture are early events in Alzheimer s disease pathogenesis MAP1B and MAP2 are sequestered by hyperphosphorylated tau in neurofibrillary tangles one of the major hallmarks of this disease All together these data led us to hypothesize that Kidins220 could be altered in Alzheimer s disease During the last year we have published that Kidins220 is increased in

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/unidades/dep_fisio?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_E1za&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_E1za_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_E1za_id=69&_APGIportlet_WAR_APIIBportlet_INSTANCE_E1za_idJefe=463&_APGIportlet_WAR_APIIBportlet_INSTANCE_E1za_menu=intro (2015-08-08)
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