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  • Department of Metabolism and Cell Signaling - iib.uam.es
    Signaling Research Groups Research Departments Cancer Biology Department Department of Endocrine and Nervous System Pathophysiology Department of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Laboratory of José González Castaño Introduction Sorry we cannot display the information requested at this time González Castaño José Catedrático Introduction Staff Research topics Publications Additional Information Navigation Presentation Welcome Location History Biography of

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/unidades/dep_meta?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_A2aT&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_A2aT_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_A2aT_id=52&_APGIportlet_WAR_APIIBportlet_INSTANCE_A2aT_idJefe=97&_APGIportlet_WAR_APIIBportlet_INSTANCE_A2aT_menu=intro (2015-08-08)
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  • Department of Metabolism and Cell Signaling - iib.uam.es
    and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications María A Pajares group Introduction The interests of my laboratory is focussed in the study of the structure function relationships of proteins involved in several pathologies mainly those related to methionine metabolism For this purpose we used in vitro and in vivo techniques that allow detection of changes in folding association interactions subcelular localization activity or regulation of these enzymes To date we have identified from key active site residues to post translational modifications involved in the control of oligomerization processes or folding intermediates Recently we demonstrated expression of some enzymes of this pathway MAT I III in many tissues where their existence was unknown Additionally in those tissues with low expression surprisingly the proteins localize to the nucleus instead to the cytoplasm that was consider their exclusive location Moreover we have been able to map the areas involved in both cytoplasmic retention and nuclear loacalization as well as to demonstrate that nuclear accumulation correlates with increases in specific epigenetic modifications Now we are centered in the study of the mechanisms that control these processes and their putative pathological alterations Pajares Tarancón

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/unidades/dep_meta?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_A2aT&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_A2aT_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_A2aT_id=41&_APGIportlet_WAR_APIIBportlet_INSTANCE_A2aT_idJefe=187&_APGIportlet_WAR_APIIBportlet_INSTANCE_A2aT_menu=intro (2015-08-08)
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  • Department of Metabolism and Cell Signaling - iib.uam.es
    small membrane vesicles nanovesicles formed by inward budding of the limiting membrane of late endosomes into their lumen The exosomes accumulate as intraluminal vesicles into secretory vesicles multivesicular bodies MVBs The stimulation of cells from diverse lineages induces the fusion of the limiting membrane of the MVBs with the plasma membrane and the secretion of exosomes Fig 1 Several evidences support the hypothesis that exosomes represent a novel modality of intercellular communication particullarly in the immune system In the immune system T lymphocyte activation with antigen through the T cell receptor TCR induces the acquisition of essential effector functions and controls the activation proliferation and apoptosis of T lymphocytes In some of these biological responses which include the cytotoxic activity exerted by cytotoxic T lymphocytes CTLs T lymphocyte activation and activation induced cell death AICD processes the exosomes appear to play an important role The MVBs from cytotoxic T lymphocytes CTLs are called lytic granules Fig 1 Upon challenge with antigen CTLs develop different mechanisms to induce the apoptosis of target cells Included among these strategies the inducible expression of Fas ligand FasL in lytic granules and its polarized secretion at the immune synapse are thought to be important mediators of CTL mediated killing In addition FasL contributes to the homeostatic control of the T lymphoid compartment that occurs through activation induced cell death AICD Regarding FasL function it has been shown that the secretion of bioactive apoptosis inducer FasL into exosomes constitutes an important mechanism controlling FasL activity Therefore our aims are 1 To gain insights into the mechanisms by which T lymphocytes control the polarised traffic of MVBs lytic granules and regulate the secretion of exosomes 2 To establish the role of pro apoptotic exosomes in the cytotoxicity mediated by CTLs and homeostatic AICD With all these knowledge

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/unidades/dep_meta?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_A2aT&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_A2aT_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_A2aT_id=81&_APGIportlet_WAR_APIIBportlet_INSTANCE_A2aT_idJefe=987&_APGIportlet_WAR_APIIBportlet_INSTANCE_A2aT_menu=intro (2015-08-08)
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  • Department of Metabolism and Cell Signaling - iib.uam.es
    Cancer Biology Department Department of Endocrine and Nervous System Pathophysiology Department of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Dual role of COX 2 in liver pathology Introduction Cyclooxygenase COX is a key regulatory step in the biosynthesis of prostanoids Prostaglandins are implicated in homeostatic processes like platelet aggregation maintaining of gastric mucose reproduction etc in addition these compounds play an important role in the onset of inflammation mitogenic responses and cancer Two COX isoenzymes have been identified COX 1 is ubiquitous and constitutively expressed in a wide variety of tissues and is responsible for the low and continuous prostaglandin synthesis required in tissue homeostasis COX 2 is undetectable in most tissues however a variety of extracellular and intracellular stimuli such inflammation and other cellular stresses can rapidly induce COX 2 in a variety of cell types COX 2 is also related with cellular growth and carcinogenesis Our group study the relationship between COX 2 expression and liver pathology by using different experimental models and human biopsies and the molecular mechanisms implicated in these processes Martín Sanz Paloma Investigador Científico Introduction Staff Research topics Publications Additional Information Navigation

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/unidades/dep_meta?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_A2aT&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_A2aT_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_A2aT_id=110&_APGIportlet_WAR_APIIBportlet_INSTANCE_A2aT_idJefe=1291&_APGIportlet_WAR_APIIBportlet_INSTANCE_A2aT_menu=intro (2015-08-08)
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  • Department of Metabolism and Cell Signaling - iib.uam.es
    SIME Microscopy Directory Activities Calendar Scientific Events News RSS feed aggregators Intranet Internal Tools Internal Information iib uam es Research Research Departments Department of Metabolism and Cell Signaling Research Groups Research Departments Cancer Biology Department Department of Endocrine and Nervous System Pathophysiology Department of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Preclinical models and new therapies Introduction The goals of our laboratory are 1 to identify and study new genes involved in tumor development and progression 2 to generate new mouse models of human diseases with preclinical interest and 3 to translate this knowledge into clinical therapies by identifying and testing new chemotherapeutic drugs and immuno modulatory agents in patient tumor cells and preclinical mouse models Key words New therapies chronic lymphocytic leukemia CLL lymphoma cancer inflammation autoimmunity type 2 diabetes transgenic mice knock out mice TNF R associated factors TRAF TRIM37 Zapata Hernández Juan Manuel Científico Titular Introduction Staff Research topics Publications Additional Information Navigation Presentation Welcome Location History Biography of Alberto Sols Organization Organization chart Management Administration Institute Board Faculty Board Committees Commissions Research Research Groups Research Departments Scientific Reports Publications Services Administration and Accounting Warehouse

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/unidades/dep_meta?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_A2aT&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_A2aT_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_A2aT_id=117&_APGIportlet_WAR_APIIBportlet_INSTANCE_A2aT_idJefe=1783&_APGIportlet_WAR_APIIBportlet_INSTANCE_A2aT_menu=intro (2015-08-08)
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  • Department of Experimental Models of Human Disease - iib.uam.es
    Cultures Non Invasive Neurofunctional Evaluation ENNI Histology Scientific Photography and Drawing Facility Sterilization and Culture Media Preparation Radiation Protection Genomics MRISS IT Services SIME Microscopy Directory Activities Calendar Scientific Events News RSS feed aggregators Intranet Internal Tools Internal Information iib uam es Research Research Departments Department of Experimental Models of Human Disease Research Groups Research Departments Cancer Biology Department Department of Endocrine and Nervous System Pathophysiology Department of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Ion Channels Lab II Introduction We focus in the analysis of the pharmacological and physiological modulation of human cardiac ion channels and in the composition and regulation of their signal complexes In order to perform our investigations we use patch clamp and molecular biology techniques González Gallego Teresa Investigador Contratado Introduction Staff Research topics Publications Additional Information Navigation Presentation Welcome Location History Biography of Alberto Sols Organization Organization chart Management Administration Institute Board Faculty Board Committees Commissions Research Research Groups Research Departments Scientific Reports Publications Services Administration and Accounting Warehouse Digital Library Quality Control Labware Washing Facility Technical Support Biological Safety Comparative Medicine Cell Cultures Non Invasive Neurofunctional Evaluation ENNI Histology Scientific Photography

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/unidades/dep_model?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_pX74&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_pX74_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_pX74_id=1014&_APGIportlet_WAR_APIIBportlet_INSTANCE_pX74_idJefe=1316&_APGIportlet_WAR_APIIBportlet_INSTANCE_pX74_menu=intro (2015-08-08)
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  • Department of Experimental Models of Human Disease - iib.uam.es
    of Technology 1978 1981 USA Sabbatical Stay at Harvard Medical School 1993 1994 USA Group Leader in the Biochemistry Department at the School of Medicine UAM since 1986 Full Professor of Biochemistry since 2007 Professor Cervera has served as coordinator of the Ph D program at the Biochemistry Department since 2000 to 2007 as Vice director of the Instituto Investigaciones Biomédicas Biomedical Research Centre a joint UAM CSIC centre secretary of the Department of Biochemistry at the UAM and as Academic Secretary of the School of Medicine at the UAM Research Interest In the Cervera lab a group of research associates postdoctoral fellows Ph D candidates master s students and undergraduates collaborate to study the basic regulatory mechanisms that modulate levels of transcription in the development of muscle diversity The lab produces transgenic strains of Drosophila to study how muscle gene regulatory regions affect expression levels in muscle subtypes and during muscle development In parallel we are also studying the relevance of the phenotypic and functional changes in coordinated mitochondrial production during muscle development Thus we will examine the magnitude of the adaptive increase or decrease in skeletal muscle mitochondrial content in response to development or re modelling in different pathologies The lab adopts integrated strategies for these studies transgenic studies comparative genomics bioinformatics quantitative RT PCR functional studies of the muscle in vivo transfection of muscle fibres in situ hybridisation and immuno staining to study patterns of expression in muscle In the lab we will take advantage of different cell model systems as human or Drosophila myoblastoid cells or animal models such as Drosophila or mouse The lab has operated for nearly 25 years with funding from the European Union National and Community Plans Professor Cervera has collaborated with academics from Spain universities from the University of California in

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/unidades/dep_model?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_pX74&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_pX74_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_pX74_id=62&_APGIportlet_WAR_APIIBportlet_INSTANCE_pX74_idJefe=39&_APGIportlet_WAR_APIIBportlet_INSTANCE_pX74_menu=intro (2015-08-08)
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  • Department of Experimental Models of Human Disease - iib.uam.es
    Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Magnetic resonance in the study of the central nervous system Introduction Cancer is one of the main caused of death in EU and other developed countries Current techniques can only diagnose and treat the late symptoms of cancer what it is getting this disease in a chronic process Nowadays there are more then 30 angiogenic inhibitors in clinical trials nevertheless there are not appropriate procedures to visualize and monitor the effectiveness of these therapies Magnetic Resonance Imaging MRI Spectroscopy MRS and Spectroscopic Imaging MRSI technologies provide a great potential to solve this situation in a near future These methodologies make possible the in vivo study among other parameters of vascularization oxygenation level pH and tumoral metabolism in a non invasive way allowing direct monitoring of different antitumoral therapies In our research group the main objective is focused in the development of new MR methodologies that afford the possibility of in vivo characterization of the tumoral microenvironment and visualization of neovascularization and tumoral metabolism That will drive us to a better understanding of the physiological and biochemical bases of connections between these

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/unidades/dep_model?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_pX74&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_pX74_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_pX74_id=113&_APGIportlet_WAR_APIIBportlet_INSTANCE_pX74_idJefe=820&_APGIportlet_WAR_APIIBportlet_INSTANCE_pX74_menu=intro (2015-08-08)
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