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  • Research Groups - iib.uam.es
    Cot tpl 2 is involved in innate and adaptive immunity and its role in inflammation cannot be replaced by any other protein Thus there is now an enormous interest in the development of small compounds to specifically block Cot tpl2 activity to identify new therapeutic anti inflammatory agents To fully understand the inflammatory processes whole animal models have to be used therefore we have generated a Cot tpl 2 and a Cot tpl 2 KD mouse We decided to generate not only the Cot tpl 2 KO mice but also the Cot tpl 2 K IN mouse because Cot is stabilized in resting cells by the association with p105 NFkB the precursor of the p50 NFkB protein The Knock in mouse is just the tool to distinguish whether it is the Cot protein or the kinase activity of Cot that is required in this phenomenon Thanks to these tools we have been able to show that Cot Tpl2controls Akt and p70S6K phosphorylation in LPS stimulated macrophages Analysis of the intracellular signaling using the same experimental setting reveals among other things that the intracellular levels of IkBa and NO synthase as well as the phosphorylation levels of p38 and JNK are also modulated by Cot Tpl2 All these data reveal a novel role for the Cot tpl2 pathway in mediating TLR activation of the Akt mTOR p70 S6k pathway allowing Cot tpl2 to fine control the activation state of other signalling pathways We have also been able to show that Cot Tpl2 regulates RSK and 4E BP phosphorylation in LPS poli I C or Zymosan stimulated bone marrow derived macrophages BMDM The dissociation of the 4E BP eIF4E complex is a key event in the cap dependent mRNA translation initiation This process is dramatically reduced reduced in LPS stimulated macrophages when

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=56&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=2&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=lineas (2015-08-08)
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  • Research Groups - iib.uam.es
    Department of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Laboratory of Susana Alemany de la Peña Publications Scientific Report 2011 2012 Scientific Report 2008 2010 Scientific Report 2006 2007 Scientific Report 2004 2005 Scientific Report 2002 2003 Scientific Report 2000 2001 All publications of the principal investigator View publications Back Introduction Staff Research topics Publications Additional Information Navigation

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=56&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=2&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=public (2015-08-08)
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  • Research Groups - iib.uam.es
    Comparative Medicine Cell Cultures Non Invasive Neurofunctional Evaluation ENNI Histology Scientific Photography and Drawing Facility Sterilization and Culture Media Preparation Radiation Protection Genomics MRISS IT Services SIME Microscopy Directory Activities Calendar Scientific Events News RSS feed aggregators Intranet Internal Tools Internal Information iib uam es Research Research Groups Research Groups Research Departments Cancer Biology Department Department of Endocrine and Nervous System Pathophysiology Department of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Laboratory of Susana Alemany de la Peña Additional Information Department the Laboratory belongs to Department of Metabolism and Cell Signaling Scientific Reports available Scientific Reports 2011 2012 Scientific Reports 2008 2010 Scientific Reports 2006 2007 Scientific Reports 2004 2005 Scientific Reports 2002 2003 Scientific Reports 2000 2001 Introduction Staff Research topics Publications Additional Information Navigation Presentation Welcome Location History Biography of Alberto Sols Organization Organization chart Management Administration Institute Board Faculty Board Committees Commissions Research Research Groups Research Departments Scientific Reports Publications Services Administration and Accounting Warehouse Digital Library Quality Control Labware Washing Facility Technical Support Biological Safety Comparative Medicine Cell Cultures Non Invasive Neurofunctional Evaluation ENNI Histology Scientific Photography and Drawing Facility Sterilization and Culture Media

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=56&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=2&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=info (2015-08-08)
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  • Directory - iib.uam.es
    Fernández Moreno Miguel Category Profesor Titular Position Comisión de Biblioteca Comisión de Almacén Compras y Equipamiento Laboratory Laboratory of Miguel Fernández Moreno B 19 Department Department of Experimental Models of Human Disease Phone Number 34 91 497 3129 Fax 34 91 497 5353 34 91 585 4401 E Mail miguelfm Publications View publications New Search Back Navigation Presentation Welcome Location History Biography of Alberto Sols Organization Organization chart Management Administration

    Original URL path: https://www.iib.uam.es/portal/en/personal?p_p_id=APPERSportlet_WAR_APIIBportlet_INSTANCE_vAb1&p_p_lifecycle=0&p_p_col_id=column-3&p_p_col_count=1&_APPERSportlet_WAR_APIIBportlet_INSTANCE_vAb1_idPersona=288&_APPERSportlet_WAR_APIIBportlet_INSTANCE_vAb1_action=detail_person (2015-08-08)
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  • Research Groups - iib.uam.es
    Cancer Biology Department Department of Endocrine and Nervous System Pathophysiology Department of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Laboratory of Miguel Fernández Moreno Staff Head of Group Fernández Moreno Miguel Estancia Formación Cruz Bermudez Alberto Vicente Blanco Ramiro J Introduction Staff Research topics Publications Additional Information Navigation Presentation Welcome Location History Biography of Alberto Sols Organization Organization

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=75&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=288&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=miembros (2015-08-08)
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  • Research Groups - iib.uam.es
    Research Groups Research Departments Cancer Biology Department Department of Endocrine and Nervous System Pathophysiology Department of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Laboratory of Miguel Fernández Moreno Research topics Could not find any element Introduction Staff Research topics Publications Additional Information Navigation Presentation Welcome Location History Biography of Alberto Sols Organization Organization chart Management Administration Institute Board

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=75&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=288&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=lineas (2015-08-08)
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  • Research Groups - iib.uam.es
    Departments Cancer Biology Department Department of Endocrine and Nervous System Pathophysiology Department of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Laboratory of Miguel Fernández Moreno Publications Scientific Report 2008 2010 All publications of the principal investigator View publications Back Introduction Staff Research topics Publications Additional Information Navigation Presentation Welcome Location History Biography of Alberto Sols Organization Organization chart

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=75&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=288&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=public (2015-08-08)
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  • Research Groups - iib.uam.es
    Department of Endocrine and Nervous System Pathophysiology Department of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Laboratory of Miguel Fernández Moreno Additional Information Department the Laboratory belongs to Department of Experimental Models of Human Disease Scientific Reports available Scientific Reports 2008 2010 Introduction Staff Research topics Publications Additional Information Navigation Presentation Welcome Location History Biography of Alberto Sols

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=75&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=288&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=info (2015-08-08)
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