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  • Directory - iib.uam.es
    Directory Directory IIBM Directory Service Belandia Gómez Borja Category Científico Titular Position Director a de Departamento Laboratory Laboratory of Borja Belandia Gómez 1 5 2 Department Department of Cancer Biology Phone Number 34 91 585 4429 Fax 34 91 585 4401 E Mail bbelandia Publications View publications New Search Back Navigation Presentation Welcome Location History Biography of Alberto Sols Organization Organization chart Management Administration Institute Board Faculty Board Committees Commissions

    Original URL path: https://www.iib.uam.es/portal/en/personal?p_p_id=APPERSportlet_WAR_APIIBportlet_INSTANCE_vAb1&p_p_lifecycle=0&p_p_col_id=column-3&p_p_col_count=1&_APPERSportlet_WAR_APIIBportlet_INSTANCE_vAb1_idPersona=18&_APPERSportlet_WAR_APIIBportlet_INSTANCE_vAb1_action=detail_person (2015-08-08)
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  • Research Groups - iib.uam.es
    Research Departments Cancer Biology Department Department of Endocrine and Nervous System Pathophysiology Department of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Laboratory of Borja Belandia Gómez Staff Head of Group Belandia Gómez Borja Investigador Contratado López Mateo Irene Introduction Staff Research topics Publications Additional Information Navigation Presentation Welcome Location History Biography of Alberto Sols Organization Organization chart Management

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=88&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=18&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=miembros (2015-08-08)
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  • Research Groups - iib.uam.es
    the BAF57 gene from 100 human primary breast tumours and we have found two new BAF57 mutations that also generate truncated BAF57 proteins similar to that found previously in BT549 cells The expression of these novel BAF57 mutants has abnormally high estrogen receptor alpha ER α coactivating potential suggesting that they might be involved in the aberrant estrogen dependent proliferation that occur in the majority of breast tumors that retain ER α expression In addition the mutations in BAF57 affect its functional interaction with the androgen receptor and ETS2 two transcription factors that play an important role in breast cell biology Therefore mutations in BAF57 could impinge on several oncogenic signaling pathways contributing to the origin and or development of breast cancer Regulation of p53 activity by HEY1 molecular mechanisms HEY1 is a co transcriptional regulator that belongs to the bHLH Orange family HEY1 mediates juxtacrine signals transmitted through the Notch receptor Upon Notch pathway activation HEY1 expression increases and it accumulates in the nucleus where it acts as a transcriptional repressor HEY1 has recently gained relevance in cancer because of its role as a transcriptional activator of the p53 tumour suppressor The p53 protein is a sequence specific transcription factor that is activated in response to most situations in which cells undergo physiological stress and plays a key role in the control of the signalling pathways that trigger the cellular responses necessary to repair cell damage or to eliminate oncogenic cells In addition many drugs commonly used in anticancer therapies act by activating p53 dependent pathways and therefore this signalling pathway is a key target for development of new therapies against cancer We have recently described that expression of HEY1 induces cell cycle arrest in human osteosarcoma cell lines U2OS in a p53 dependent manner and it also sensitizes

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=88&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=18&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=lineas (2015-08-08)
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  • Research Groups - iib.uam.es
    Endocrine and Nervous System Pathophysiology Department of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Laboratory of Borja Belandia Gómez Publications Scientific Report 2011 2012 Scientific Report 2008 2010 Scientific Report 2006 2007 Scientific Report 2004 2005 All publications of the principal investigator View publications Back Introduction Staff Research topics Publications Additional Information Navigation Presentation Welcome Location History Biography

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=88&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=18&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=public (2015-08-08)
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  • Research Groups - iib.uam.es
    Nervous System Pathophysiology Department of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Laboratory of Borja Belandia Gómez Additional Information Department the Laboratory belongs to Department of Cancer Biology Scientific Reports available Scientific Reports 2011 2012 Scientific Reports 2008 2010 Scientific Reports 2006 2007 Scientific Reports 2004 2005 Introduction Staff Research topics Publications Additional Information Navigation Presentation Welcome Location

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=88&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=18&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=info (2015-08-08)
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  • Directory - iib.uam.es
    uam es Directory Directory IIBM Directory Service González Gallego Teresa Category Investigador Contratado Laboratory Ion Channels Lab II 1 13 Department Department of Experimental Models of Human Disease Phone Number 34 91 585 4499 Fax 34 91 585 4401 E Mail tgonzalez Publications View publications New Search Back Navigation Presentation Welcome Location History Biography of Alberto Sols Organization Organization chart Management Administration Institute Board Faculty Board Committees Commissions Research Research

    Original URL path: https://www.iib.uam.es/portal/en/personal?p_p_id=APPERSportlet_WAR_APIIBportlet_INSTANCE_vAb1&p_p_lifecycle=0&p_p_col_id=column-3&p_p_col_count=1&_APPERSportlet_WAR_APIIBportlet_INSTANCE_vAb1_idPersona=1316&_APPERSportlet_WAR_APIIBportlet_INSTANCE_vAb1_action=detail_person (2015-08-08)
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  • Research Groups - iib.uam.es
    Groups Research Groups Research Departments Cancer Biology Department Department of Endocrine and Nervous System Pathophysiology Department of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Ion Channels Lab II Staff Head of Group González Gallego Teresa Introduction Staff Research topics Publications Additional Information Navigation Presentation Welcome Location History Biography of Alberto Sols Organization Organization chart Management Administration Institute Board

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=1014&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=1316&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=miembros (2015-08-08)
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  • Research Groups - iib.uam.es
    Cancer Biology Department Department of Endocrine and Nervous System Pathophysiology Department of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Ion Channels Lab II Publications Could not find any element Back All publications of the principal investigator View publications Back Introduction Staff Research topics Publications Additional Information Navigation Presentation Welcome Location History Biography of Alberto Sols Organization Organization chart

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=1014&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=1316&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=public (2015-08-08)
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