archive-es.com » ES » U » UAM.ES

Total: 552

Choose link from "Titles, links and description words view":

Or switch to "Titles and links view".
  • Research Groups - iib.uam.es
    Department of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Novel targets in neurodegeneration and neuroprotection Publications Scientific Report 2011 2012 Scientific Report 2008 2010 Scientific Report 2006 2007 Scientific Report 2004 2005 Scientific Report 2002 2003 Scientific Report 2000 2001 All publications of the principal investigator View publications Back Introduction Staff Research topics Publications Additional Information Navigation Presentation

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=69&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=463&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=public (2015-08-08)
    Open archived version from archive


  • Directory - iib.uam.es
    Investigador Científico Position Comisión de Equipamiento Comisión de Cultivos y Medios Comisión de Citometría de Flujo y Microscopia de Fluorescencia Laboratory T lymphocyte activation and apoptosis laboratory C 20 Department Department of Metabolism and Cell Signaling Phone Number 34 91 497 3117 Fax 34 91 497 5353 34 91 585 4401 E Mail mizquierdo Publications View publications New Search Back Navigation Presentation Welcome Location History Biography of Alberto Sols Organization

    Original URL path: https://www.iib.uam.es/portal/en/personal?p_p_id=APPERSportlet_WAR_APIIBportlet_INSTANCE_vAb1&p_p_lifecycle=0&p_p_col_id=column-3&p_p_col_count=1&_APPERSportlet_WAR_APIIBportlet_INSTANCE_vAb1_idPersona=987&_APPERSportlet_WAR_APIIBportlet_INSTANCE_vAb1_action=detail_person (2015-08-08)
    Open archived version from archive

  • Research Groups - iib.uam.es
    Endocrine and Nervous System Pathophysiology Department of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications T lymphocyte activation and apoptosis laboratory Staff Head of Group Izquierdo Pastor Manuel Estancia Formación Bello Morales Arroyo Ángeles R Fraile Ramos Alberto Merchán Martín Álvaro Asesor Colaborador Guerra García Susana Introduction Staff Research topics Publications Additional Information Navigation Presentation Welcome Location History Biography

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=81&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=987&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=miembros (2015-08-08)
    Open archived version from archive

  • Research Groups - iib.uam.es
    of DGKalpha on activation induced cell death AICD in a T cell line and primary T lymphoblasts The pharmacologic inhibition of DGKalpha increases the secretion of lethal exosomes bearing mFasL and subsequent apoptosis On the contrary the over activation of the DGKalpha pathway inhibits exosome secretion and subsequent apoptosis DGKalpha was found associated with the trans Golgi Network and late endosomal compartments Our results support the hypothesis that DGKalpha effect on apoptosis occurs via the regulation of the release of lethal exosomes by the exocytic pathway and point out that the spatial orchestration of the different pools of DAG plasma membrane and Golgi membranes by DGKalpha is crucial for the control of cell activation but also for the regulation of the secretion of lethal exosomes which in turn controls cell death Deciphering the role of DGK alpha during the secretory traffic of exosomes in T lymphocytes Mazzeo C Cantrell D Merida I Marsh M Fraile A Calvo V Izquierdo M Multivesicular bodies MVBs are endocytic compartments that contain intraluminal vesicles formed by inward budding from the limiting membrane of endosomes FIG 1 In T lymphocytes these intraluminal vesicles contain pro apoptotic Fas ligand FasL that may be secreted as lethal exosomes upon fusion of MVBs with the plasma membrane Diacylglycerol kinase alpha DGKalpha regulates the secretion of exosomes but it is unclear how this control is mediated T lymphocyte activation increases the number of MVBs that contain FasL DGKalpha is recruited to MVBs and exosomes in which it has a double function DGKalpha kinase activity exerts a negative role in the formation of mature MVBs as we demonstrate by using a specific inhibitor Downmodulation of DGKalpha protein siRNA resulted in inhibition of both the polarization of MVBs towards immune synapse and exosome secretion The negative effect of DGKalpha kinase activity

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=81&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=987&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=lineas (2015-08-08)
    Open archived version from archive

  • Research Groups - iib.uam.es
    of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications T lymphocyte activation and apoptosis laboratory Additional Information Department the Laboratory belongs to Department of Metabolism and Cell Signaling Scientific Reports available Scientific Reports 2011 2012 Scientific Reports 2008 2010 Scientific Reports 2006 2007 Scientific Reports 2004 2005 Scientific Reports 2002 2003 Introduction Staff Research topics Publications Additional Information Navigation

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=81&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=987&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=info (2015-08-08)
    Open archived version from archive

  • Research Groups - iib.uam.es
    development Research topics Identification of genes required for neoplastic transformation Multiple genetic alterations are required for transformation of a normal cell into a cancer cell These alterations endow cells to gain unlimited proliferation potential immortalization evade immune system surveillance resist apoptotic cues and acquire anchorage independent growth and invasiveness capacity We are interested in uncovering genes mediating neoplastic progression beyond the immortalization step We compared gene expression profiles between immortalized and transformed cells in several tumor models and we have already identified numerous genes whose expression changes between these cell states We have also started to address the contribution of some of these genes to the progression of immortalized cells to a transformed state using both cell and animal models We also investigate the mechanisms mediating the role of these genes in transformation These studies may perhaps identify genes critically involved in this progression that may become targets for the development of more specific and less toxic cancer therapies than those currently used Molecular characterization of cardiovascular diseases Cardiovascular diseases are among the primary causes of death in the developed world Pathologies such as hypertension atherosclerosis aneurysm and restenosis are all associated to extensive vascular wall remodeling Angiotensin II AngII and vascular smooth muscle cells VSMCs play essential roles in vascular wall remodelingthrough relatively unknown mechanisms We are interested in determining how AngII and VSMCs mediate vessel remodeling in vascular pathologies To gain insight into this issue we have screened whole genome arrays for genes whose expression is regulated in VSMCs by AngII Using mouse models of atherosclerosis aneurysm and restenosis we have already found that one of these genes is essential for the development of these pathologies Indeed targeted deletion of this gene protected mice against them We are now investigating the molecules mediating the involvement of this gene

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=71&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=681&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=lineas (2015-08-08)
    Open archived version from archive

  • Research Groups - iib.uam.es
    Pathophysiology Department of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Molecular characterization of tumor formation and vascular pathologies development Publications Scientific Report 2011 2012 Scientific Report 2008 2010 Scientific Report 2006 2007 Scientific Report 2004 2005 Scientific Report 2002 2003 All publications of the principal investigator View publications Back Introduction Staff Research topics Publications Additional Information Navigation Presentation

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=71&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=681&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=public (2015-08-08)
    Open archived version from archive

  • Research Groups - iib.uam.es
    of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Molecular characterization of tumor formation and vascular pathologies development Additional Information Department the Laboratory belongs to Department of Cancer Biology Scientific Reports available Scientific Reports 2011 2012 Scientific Reports 2008 2010 Scientific Reports 2006 2007 Scientific Reports 2004 2005 Scientific Reports 2002 2003 Introduction Staff Research topics Publications Additional Information

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=71&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=681&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=info (2015-08-08)
    Open archived version from archive



  •