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  • Directory - iib.uam.es
    Directory IIBM Directory Service Jiménez Cuenca Benilde Category Profesor Titular Position Comite de Ética en Experimentación Humana y Animal CEEHA Laboratory Tumor angiogenesis 2 5 1 Department Department of Cancer Biology Phone Number 34 91 585 4484 Fax 34 91 585 4401 E Mail bjimenez Publications View publications New Search Back Navigation Presentation Welcome Location History Biography of Alberto Sols Organization Organization chart Management Administration Institute Board Faculty Board Committees

    Original URL path: https://www.iib.uam.es/portal/en/personal?p_p_id=APPERSportlet_WAR_APIIBportlet_INSTANCE_vAb1&p_p_lifecycle=0&p_p_col_id=column-3&p_p_col_count=1&_APPERSportlet_WAR_APIIBportlet_INSTANCE_vAb1_idPersona=111&_APPERSportlet_WAR_APIIBportlet_INSTANCE_vAb1_action=detail_person (2015-08-08)
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  • Research Groups - iib.uam.es
    Departments Cancer Biology Department Department of Endocrine and Nervous System Pathophysiology Department of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Tumor angiogenesis Staff Head of Group Jiménez Cuenca Benilde Estancia Formación Carmona Talavera Diego Deguiz Lasso María Laura Introduction Staff Research topics Publications Additional Information Navigation Presentation Welcome Location History Biography of Alberto Sols Organization Organization chart Management

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=72&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=111&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=miembros (2015-08-08)
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  • Research Groups - iib.uam.es
    of PEDF in melanoma cells By global gene expression analysis using microarrays we have identified genes regulated by PEDF in highly aggressive melanomas transduced with lentivirus PEDF PEDF modulates de expression of genes involved in the control of angiogenesis migration invasion and aggressiveness of melanoma in the sense expected for inhibition of these biological responses Observed modulation of the gene expression profile corresponds with the antitumoral and antimetastatic effects that we previously characterized in diverse mouse models of melanoma We have studied in more detail the effect of PEDF on regulators of angiogenesis PEDF blocks the production of proangiogenic VEGF and IL8 by melanoma cells inverting the angiogenic balance towards reduced capability to vascularize Additionally we have described relevant aspects of the mechanism underlying inhibition of melanoma migration and invasion by PEDF PEDF inhibits the two modes of melanoma migration and invasion ameboid type and mesenchymal type through inhibition of rhoA and activation of rac Alteration of the balance of rho and rac activity by PEDF in melanoma cells impedes plasma membrane localization of MT1 MMP This mechanism justifies the potent antimetastatic effects of PEDF we have encountered in the different mouse models utilized Identification of regulators of PEDF in melanoma We have previously described that PEDF expression is lost during the malignant progression of human melanoma In the period covered by this report we have focused on the identification of regulators of PEDF relevant in the context of melanoma progression PEDF is negatively regulated by hypoxia in melanocytes and melanoma cells This regulation is HIF independent in agreement with other repressive mechanisms by hypoxia We have found that negative regulation of PEDF by hypoxia is mediated by a post transcriptional mechanism executed by autophagy We have identified a second mechanism responsible of the loss of PEDF expression in nevi

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=72&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=111&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=lineas (2015-08-08)
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  • Research Groups - iib.uam.es
    and Nervous System Pathophysiology Department of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Tumor angiogenesis Publications Scientific Report 2011 2012 Scientific Report 2008 2010 Scientific Report 2006 2007 Scientific Report 2004 2005 Scientific Report 2002 2003 All publications of the principal investigator View publications Back Introduction Staff Research topics Publications Additional Information Navigation Presentation Welcome Location History Biography

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=72&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=111&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=public (2015-08-08)
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  • Research Groups - iib.uam.es
    System Pathophysiology Department of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Tumor angiogenesis Additional Information Department the Laboratory belongs to Department of Cancer Biology Scientific Reports available Scientific Reports 2011 2012 Scientific Reports 2008 2010 Scientific Reports 2006 2007 Scientific Reports 2004 2005 Scientific Reports 2002 2003 Introduction Staff Research topics Publications Additional Information Navigation Presentation Welcome Location

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=72&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=111&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=info (2015-08-08)
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  • Directory - iib.uam.es
    Directory Directory IIBM Directory Service Santisteban Sanz Pilar Category Profesor Investigación Position Comisión Mixta Comisión de Animalario Laboratory Santisteban Sanz Pilar 2 9 Department Department of Pathophysiology Endocrine and Nervous System Phone Number 34 91 585 4455 Fax 34 91 585 4401 E Mail psantisteban Publications View publications New Search Back Navigation Presentation Welcome Location History Biography of Alberto Sols Organization Organization chart Management Administration Institute Board Faculty Board Committees

    Original URL path: https://www.iib.uam.es/portal/en/personal?p_p_id=APPERSportlet_WAR_APIIBportlet_INSTANCE_vAb1&p_p_lifecycle=0&p_p_col_id=column-3&p_p_col_count=1&_APPERSportlet_WAR_APIIBportlet_INSTANCE_vAb1_idPersona=237&_APPERSportlet_WAR_APIIBportlet_INSTANCE_vAb1_action=detail_person (2015-08-08)
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  • Research Groups - iib.uam.es
    Evaluation ENNI Histology Scientific Photography and Drawing Facility Sterilization and Culture Media Preparation Radiation Protection Genomics MRISS IT Services SIME Microscopy Directory Activities Calendar Scientific Events News RSS feed aggregators Intranet Internal Tools Internal Information iib uam es Research Research Groups Research Groups Research Departments Cancer Biology Department Department of Endocrine and Nervous System Pathophysiology Department of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Santisteban Sanz Pilar Staff Head of Group Santisteban Sanz Pilar Contratado Doctor Zaballos Sánchez Miguel Angel Investigador Contratado Fernández Méndez Celia Koumarianou Petrina Wert Lamas León Becario Predoctoral Acuña Ruíz Adrián López Márquez Aristides Estancia Formación Morillo Bernal Jesús Ramírez Moya Julia A Estudiante Carrasco López Carlos Técnico Contratado Superior Martínez Cano Andrea Asesor Colaborador Castro Calvo Alejandro Riesco Eizaguirre Garcilaso Introduction Staff Research topics Publications Additional Information Navigation Presentation Welcome Location History Biography of Alberto Sols Organization Organization chart Management Administration Institute Board Faculty Board Committees Commissions Research Research Groups Research Departments Scientific Reports Publications Services Administration and Accounting Warehouse Digital Library Quality Control Labware Washing Facility Technical Support Biological Safety Comparative Medicine Cell Cultures Non Invasive Neurofunctional Evaluation ENNI Histology Scientific Photography

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=31&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=237&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=miembros (2015-08-08)
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  • Research Groups - iib.uam.es
    controlling the differentiation and proliferation of the thyroid gland during development and cancer Therefore using embryonic endoderm explants and inducible pluripotent iPS cells as model systems we have identify new signals Shh that specify pluripotent cells to an epithelial thyroid fate Our preliminary results suggest that the forkhead transcription factor FoxE1 could be the main target of these signals as this is a pioneer factor with the intrinsic capacity to remodel compacted chromatin facilitating the subsequent binding of the other transcription factors Titf1 NKx2 1 and Pax8 to DNA These three factors define thyroid cell identity at the onset of development however the differentiated thyroid function does not appear until 4 5 days later in the mouse implying that there are still unknown players For this reason we have performed a global analysis of in vivo Pax8 binding sites using massively parallel sequencing ChIP Seq to identify new targets and interactors that are necessary for terminal thyroid differentiation a process that includes cell migration from the floor of the pharynx to the trachea and then the follicles formation Currently we are performing the same experimental approach with FoxE1 Given that cell differentiation is a necessary process for development but is lost in cell transformation and cancer we are atudying the mechanism of the main signaling pathways TSH cAMP PKA IGF1 PI3K FoxO1 Wnt bcatenin and TGFbeta Smads that regulate the thyroid differentiated functions and cell growth Recently we have shown that BRAF V600E through TGFbeta represses thyroid differentiation inducing cancer progression Thus our current aim is to explore the effects of BRAF and TGFbeta on the extracellular remodeling metalloproteinases and on the main transcription factors which govern epithelial mesenchymal transition We also hypothesize that altered microRNA expression may contribute to thyroid carcinogenesis particularly through Sodium Iodide Symporter NIS repression Thus

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=31&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=237&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=lineas (2015-08-08)
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