archive-es.com » ES » U » UAM.ES

Total: 552

Choose link from "Titles, links and description words view":

Or switch to "Titles and links view".
  • Research Groups - iib.uam.es
    of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Laboratory of Alberto Muñoz Terol Staff Head of Group Muñoz Terol Alberto Investigador Contratado Barbáchano Becerril Antonio Fernández Barral Asunción Becario Predoctoral Costales Carrera Alba Técnico Superior Larriba Muñoz María Jesús Técnico Contratado Ferrer Mayorga Gemma Técnico Contratado Superior Cámara Ruiz Ana Belén Introduction Staff Research topics Publications Additional Information

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=33&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=173&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=miembros (2015-08-08)
    Open archived version from archive


  • Research Groups - iib.uam.es
    SMARCE KHSRP TARDBP PARP1 Cristobo et al J Proteomics 2011 By using microRNA microarrays we have been able to characterize several microRNA species as putative targets of 1 25 OH 2D3 and we selected microRNA 22 miR 22 for an in depth study We confirmed that miR 22 is induced by 1 25 OH 2D3 and that it contributes to its effects on cell proliferation and migration and on gene regulation Álvarez Díaz et al Hum Mol Genet 2012 Our data and also all others existing in the literature on the action of vitamin D and its derivatives in colon cancer have recently been reviewed by us Pereira et al Endocr Rel Cancer 2012 Finally we continue studying the biological activity of a few genes that we previously identified as targets of 1 25 OH 2D3 in colon cancer cells such as DICKKOPF 1 SPROUTY 2 and CST5 Cystatin D Vitamin D effects on Wnt beta catenin pathway and on bladder cancer Based on our own previous data which have been confirmed by other researchers in diverse biological systems indicating that 1 25 OH 2D3 antagonizes the Wnt beta catenin signaling pathway in colon cancer cells we have now performed studies in animals to analyze whether such antagonism takes place also in vivo To this end we generated animals carrying one mutated allele of the Apc tumor suppressor gene and either two one or none alleles of Vdr gene coding for the vitamin D receptor by means of appropriated crosses between Apcmin and Vdr mice Results obtained show that Vdr deficiency does not alter the number of tumors developed in mice but in contrast increases tumor growth and the number of aberrant crypt foci In addition Vdr deficiency enhances the level of nuclear beta catenin and the expression of Wnt beta catenin target genes Accordingly Vdr deficiency abolishes the capacity of 1 25 OH 2D3 to promote the relocation of beta catenin from the cell nucleus towards the plasma membrane in cultured colon cancer cells In summary we demonstrate that Vdr controls also in vivo the amount of nuclear beta catenin and that it may attenuate the impact of oncogenic mutations such as Apc loss that activate the Wnt beta catenin pathway Larriba et al PLos ONE 2011 Regarding Wnt beta catenin pathway which is cfucial in the initiation and progression of colon cancer in collaboration with Drs Héctor G Pálmer and others at the Vall d Hebron Institute of Oncologia VHIO Barcelona we have reported how the combined presence of beta catenin and FOXO3a within the cell nucleus confers resistance to the apoptosis induced by the latter and causes a profound alteration of the gene expression profile promoting metastasis in an animal model while it is linked to metastasis and lower survival in colorectal cancer patients Tenbaum et al Nat Med 2012 Notably given the action of 1 25 OH 2D3 decreasing beta catenin nuclear level these results support the proposed protective effect of this agent against colorectal cancer

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=33&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=173&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=lineas (2015-08-08)
    Open archived version from archive

  • Research Groups - iib.uam.es
    Cancer Biology Department Department of Endocrine and Nervous System Pathophysiology Department of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Preclinical models and new therapies Staff Head of Group Zapata Hernández Juan Manuel Investigador Contratado Acosta Iborra Bárbara Pérez Chacón Gema Introduction Staff Research topics Publications Additional Information Navigation Presentation Welcome Location History Biography of Alberto Sols Organization Organization

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=117&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=1783&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=miembros (2015-08-08)
    Open archived version from archive

  • Research Groups - iib.uam.es
    of Toll Like Receptors TLRs complexes thus participating in the regulation of key signaling pathways involved in cell differentiation activation and survival In the immune system TRAFs regulate lymphocyte differentiation and function tightly controling innate and adaptive immunity by regulating TNFR and TLR signaling Therefore it is not surprising that growing evidence is highlighting the role of TRAF family members in different pathologies Zapata et al 2007 Adv Exp Med Biol 597 188 Indeed studies from our laboratory using B cell specific transgenic mice allowed the identification of the role of different members of the TRAF family in tumorigenesis Zapata et al 2004 PNAS 101 16600 and in autoimmunity inflammation and cancer Zapata et al 2009 Blood 113 4595 Studies from our laboratory showed that transgenic mice expressing in B lymphocytes both BCL 2 and a TRAF2 mutant lacking the RING and zinc finger domains TRAF2DN develop small lymphocytic lymphoma SLL and chronic lymphocytic leukemia CLL with high incidence Zapata et al 2004 PNAS 101 16600 We have continued these studies to elucidate the particular role of TRAF2 in the development of CLL SLL Pérez Chacón et al 2012 J Immunol 189 1053 61 Further analysis of the expression of TRAF2 and TRAF2DN in purified B cells demonstrated that expression of both endogenous TRAF2 and transgenic TRAF2DN was negligible in Traf2 DN tg B cells compared to wild type mice This was the result of proteasome dependent degradation and rendered TRAF2DN B cells as bona fide TRAF2 deficient B cells Similar to B cells with targeted Traf2 deletion Gardam et al 2008 Immunity 28 391 401 Traf2 DN tg mice show expanded marginal zone MZ B cell population and have constitutive p100 NF kB2 processing Also TRAF3 XIAP and Bcl X L expression levels were increased while cIAP1 2 levels

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=117&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=1783&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=lineas (2015-08-08)
    Open archived version from archive

  • Research Groups - iib.uam.es
    Biology Department Department of Endocrine and Nervous System Pathophysiology Department of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Preclinical models and new therapies Publications Scientific Report 2011 2012 Scientific Report 2008 2010 All publications of the principal investigator View publications Back Introduction Staff Research topics Publications Additional Information Navigation Presentation Welcome Location History Biography of Alberto Sols Organization

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=117&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=1783&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=public (2015-08-08)
    Open archived version from archive

  • Research Groups - iib.uam.es
    of Endocrine and Nervous System Pathophysiology Department of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Preclinical models and new therapies Additional Information Department the Laboratory belongs to Department of Metabolism and Cell Signaling Scientific Reports available Scientific Reports 2011 2012 Scientific Reports 2008 2010 Introduction Staff Research topics Publications Additional Information Navigation Presentation Welcome Location History Biography of

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=117&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=1783&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=info (2015-08-08)
    Open archived version from archive

  • Directory - iib.uam.es
    Directory Service Escalante Hernández Ricardo Category Científico Titular Position Comisión de Secuenciación Comisión Científica Laboratory Functional genomics in Dictyostelium autophagy and mitochondrial dysfunction 1 2 2 Department Department of Experimental Models of Human Disease Phone Number 34 91 585 4467 Fax 34 91 585 4401 E Mail rescalante Publications View publications New Search Back Navigation Presentation Welcome Location History Biography of Alberto Sols Organization Organization chart Management Administration Institute Board

    Original URL path: https://www.iib.uam.es/portal/en/personal?p_p_id=APPERSportlet_WAR_APIIBportlet_INSTANCE_vAb1&p_p_lifecycle=0&p_p_col_id=column-3&p_p_col_count=1&_APPERSportlet_WAR_APIIBportlet_INSTANCE_vAb1_idPersona=284&_APPERSportlet_WAR_APIIBportlet_INSTANCE_vAb1_action=detail_person (2015-08-08)
    Open archived version from archive

  • Research Groups - iib.uam.es
    Nervous System Pathophysiology Department of Metabolism and Cell Signaling Department of Experimental Models of Human Disease Scientific Reports Scientific Reports in pdf format Publications Functional genomics in Dictyostelium autophagy and mitochondrial dysfunction Staff Head of Group Escalante Hernández Ricardo Sin definir Domínguez Martín Alejandra Eunice Investigador Contratado Nuñez Corcuera Beatriz Tábara Rodríguez Luis Carlos Becario Predoctoral Muñoz Braceras Sandra Introduction Staff Research topics Publications Additional Information Navigation Presentation Welcome Location

    Original URL path: https://www.iib.uam.es/portal/en/investigacion/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&p_p_lifecycle=0&p_p_state=normal&p_p_mode=view&p_p_col_id=column-3&p_p_col_count=1&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=83&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=284&_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=miembros (2015-08-08)
    Open archived version from archive



  •